HUBUNGAN KADAR ADIPONEKTIN DENGAN TIPE ACUTE CORONARY SYNDROME PADA PASIEN DIABETES MELLITUS = ASSOCIATION OF ADIPONECTIN CONCENTRATION WITH ACUTE CORONARY SYNDROME TYPES IN PATIENTS WITH DIABETES MELLITUS

Background: Diabetes Mellitus (DM) has been correlated with a significant rise in the risk of cardiovascular disease, particularly acute coronary syndrome (ACS). ACS individuals who were diabetic were statistically more likely to have a major adverse cardiovascular event (MACE) compared to non-diabetic individuals. Hypoadiponectinemia is an indicator of an increased risk of developing ACS. Objective: This study aims to determine the association of adiponectin concentration with types of ACS and to determine risk factors that have the biggest impact on adiponectin concentration in DM and ACS. Methods. A cross-sectional analytical study with simple random sampling was conducted at Cardiac Centre Dr. Wahidin Sudirohusodo Hospital. Data analysis was performed using chi-square tests. This study involved 88 subjects who were diagnosed with DM and ACS who fulfilled the study’s eligibility criteria. Results. The mean adiponectin concentration was 10.27 µg/mL. No significant association was found between adiponectin concentration and ACS type (p > 0.05). There is a significant association between dyslipidemia and adiponectin concentration (p < 0.05), with the highest proportion of subjects with dyslipidemia in the second quartile of adiponectin (Q2) at 28.4%. Conclusions. There is no significant association between adiponectin concentration with ACS types in patients with DM. Pharmacological interventions that can increase adiponectin concentration should be controlled as potential confounding factors in this study. Dyslipidemia was identified as the primary risk factor influencing adiponectin concentration.