SINTESIS DAN KARAKTERISASI SENYAWA TURUNAN 3',6-DIMETOKSI-3'',4''-(METILENDIOKSI)-2,5- EPOKSILIGNAN-4'-OL

ABSTRACT
A research synthesis, purity analysis, and characterization of
derivatives 3',6-dimethoxy-3'',4''-(methylenedioxy)-2,5-epoxyilignan-4'-ol
has been done. This study aimed to perform the synthesis, purity analysis,
and characterization of derivatives 3 ',6-dimethoxy-3'', 4'' - (methylenedioxy) -2,5-epoksilignan-4'-ol and characterized using a variety of
techniques spectroscopically in order to make sure the pure compound
derived epoksilignan. Compound 3',6-dimethoxy-3'',4''-(methylenedioxy)-
2,5- epoxyilignan-4'-ol as the main material synthesized by the reaction of
demethylation using pyridine and stirred slowly at a temperature of 18oC
for 4 hours and then stirred rapidly at a temperature of 25°C for 1 hour.
The solution was then added to a mixture of chloroform and benzene and
added NaHCO3 and MgSO4. Solution was allowed to stand until a
precipitation was formed, then filtered and dried. Synthesis of the
compounds was then analyzed its purity by TLC and column
chromatography methods to obtain a single compound. A single
compound then was characterized by several spectroscopic methods
including UV-VIS and FT-IR. Based on the IR results obtained by
comparing the initial compound 3',6-dimethoxy-3'', 4''-(methylenedioxy)-
2,5-epoxyilignan-4'-ol with compounds synthesized, visible difference
spectrum showed that initial compounds had undergone demethylation
(reduction of a methyl group) to form a carbonyl group. Percent rendamen
obtained at 85.906%.