The relationship between different dosages of mannitol 20% and osmolarity, blood sugar serum, and coagulation factors in moderate brain injury patients with increased intracranial pressure

Objective: Traumatic brain injuries have high mortality rates in many countries. Chemical parameters such as blood osmolarity, serum blood sugar, and coagulation factors can be used to assess the prognosis of a brain injury. Increased intracranial pressure and swelling of the brain are clinical manifestations of brain injury. One option for non-operative treatment is the use of mannitol (MT). This research aims to determine the dosage of MT 20% that demonstrates better levels of safety and effectiveness, based on the evaluation of 3 laboratory-test parameters. Method: This research is a prospective cohort with a total sample of 30 patients with moderate brain injuries, who are divided randomly into two groups of different dosages of MT. Results: The results are analyzed using repeated measures ANOVA tests and are significant if p < 0.05. We found differences in blood osmolarity, serum blood sugar, and coagulation factors between the two groups. A dosage of MT 20% 1 g/kgBW has a higher value than a dosage of 0.5 g/kgBW, but all were nonsignificant (p > 0.05). Conclusion: MT 20% does not affect blood osmolarity, serum blood sugar, and coagulation factors.