EFEK PEMBERIAN AGONIS RESEPTOR ADRENERGIK β3 (MIRABEGRON) TERHADAP DERAJAT INFLAMASI MUKOSA KANDUNG KEMIH PADA PENDERITA PASKA PEMASANGAN URETERAL STENT = THE EFFECT OF AGONIS RECEPTOR ADRENERGIC Β3 (MIRABEGRON) ON THE GRADE OF BLADDER MUCOSAL INFLAMMATION IN PATIENTS POST URETERAL STENT INSERTION

The ureteral stents possess numerous benefits, but they are also associated with various side effects, collectively known a stent-related syndrome (SRS).Mirabegron acts as a selective agonist for beta-3 adrenergic receptor, leading to detrusor muscle relaxation. The mirabegron is also linked to the protective effects on the bladder mucosa changes. Therefore, the research aims at investigating the effects of the mirabegron on the changes in the bladder epithelial mucosa in the subjects undergoing the ureteral stent placement. The research used the true experimental design with the randomized pre-post- controlled group approach.The subjects were divided into two groups, namely the intervention group receiving the mirabegron of 50 mg for 6 weeks and the placebo group. The followup was conducted over 6 weeks, and outcomes were assessed using biopsy data before and after the ureteral placement, along with the Ureteral Stent Symptoms Questionnaire (USSQ). The research result indicates that a total of 23 subjects is included in this research with 11 subjects in the intervention group and 12 subjects in the placebo group. After the stent placement, there is a grade 3 change in 6 subjects (26.1%) and a grade 4 change in 4 subjects (17.3%). The analysis reveals statistically significant difference in the comparison of the therapy types regarding the histopathological changes (p < 0.05). Moreover, there are statistically significant differences in USSQ scores in the mirabegron group,indicating an improvement in Lower Urinary Tract Symptoms (LUTS). It can be concluded that the mirabegron proves effective in reducing the overactive bladder occurrence, as the evidence by the improved USSQ scores and the improvement of the bladder mucosa inflammation grades.

Keyword : mirabegron, overactive bladder, stent ureter, bladder mucosa, USSQ