The Potential of Golden Sea Cucumber (Stichopus hermanii) in the Regeneration of Periodontal Tissues: a Literature Review

Periodontitis is a disease in the oral cavity most commonly experienced by humans, namely
inflammation characterized by damage to the supporting tissues of the teeth (gingiva, alveolar
bone, periodontal ligament, and cementum). Periodontitis, if left untreated, will get worse and
can lead to tooth loss. Periodontal disease can be treated with both surgical and non-surgical
methods, both of which cause injury to the periodontal tissue. It is a challenge for practitioners
to develop methods and materials that can accelerate periodontal tissues' regeneration, both
soft and hard tissues. One of the marine biotas used as an additive in periodontal therapy is a
sea cucumber. Golden sea cucumber (Stichopus hermanii) contains various bioactive
components which are very beneficial for human health. The protein content in dried sea
cucumbers is 82 g per 100 g, and about 80%is in the form of collagen. Collagen has function
as a tissue binder in regenerating bones and skin