HUBUNGAN ANTARA ASUPAN AIR TERHADAP PROGRESIFITAS LAJU FILTRASI GLOMERULUS PASIEN PENYAKIT GINJAL KRONIS = THE RELATIONSHIP BETWEEN WATER INTAKE AND THE PROGRESSIVE GLOMERULAR FILTRATION RATE OF CHRONIC KIDNEY DISEASE PATIENTS

THE RELATIONSHIP BETWEEN WATER INTAKE AND THE PROGRESSIVE GLOMERULAR FILTRATION RATE OF CHRONIC KIDNEY DISEASE PATIENTS ABSTRACT Munaqisah. The relationship between water intake and the progressive glomerular filtration rate of chronic kidney disease patients. (Supervised by Haerani Rashid, Aminuddin, Suryani As'ad, Nurpudji Taslim, and Nur Ashari). Background and objectives: The increasing incidence of chronic kidney disease in Indonesia and several previous studies assessing the relationship of water intake by evaluating all inputs including total daily water intake as well as output (urine volume) found that there is a role of fluid input on the progressivity of CKD which shows that patients who drink too much or little water tend to progress the failure of kidney function faster so we raised this study to determine and important implications for education of CKD patients regarding water intake. Methods: Prospective observational study on stage 3a, stage 3b and stage 4 CKD patients outpatient in hypertension kidney clinic of Dr. Wahidin Sudirohusodo Hospital and Makassar satellite hospital (10 participants) for 3 months. The daily average water intake was measured using a 2-liter tumbler and 24-hour urine volume was measured using a chamber pot and the results were recorded in a food diary. Creatinine levels (LFG) were collected from red blood cells and urine osmolarity from 24-hour urine. Results: The correlation between daily average water intake and delta creatinine was 0.151, p value was 0.677. The correlation between daily average water intake and delta glomerular filtration rate was -0.196, p value 0.588. The correlation between daily average water intake and 24-hour total urine was 0.625, p value 0.053, all of which indicated that the correlation was not significant. Conclusions: The physiological function of the kidneys can still function properly as evidenced by the amount of water given where the more the amount of water drunk, the more the amount of urine and urine osmolarity decreases. This study has not been able to prove the research hypothesis with research limitations.

Keywords: Chronic Kidney Disease, Water Intake, eGFR, Urine Osmolarity