HUBUNGAN EKSPRESI RESEPTOR ASIALOGLYCOPROTEIN PLASENTA DENGAN RESPON AWAL VAKSINASI HEPATITIS B PADA BAYI BARU LAHIR DARI IBU POSITIF HBsAg = ASSOCIATION OF ASIALOGLYCOPROTEIN RECEPTOR EXPRESSION IN PLACENTAL WITH EARLY RESPONSE OF HEPATITIS B VACCINATION IN NEWBORNS FROM HBsAg MOTHERS POSITIVE

HUBUNGAN EKSPRESI RESEPTOR ASIALOGLYCOPROTEIN PLASENTA DENGAN RESPON AWAL VAKSINASI HEPATITIS B PADA
BAYI BARU LAHIR DARI IBU POSITIF HBsAg
Abstrak
Latar Belakang : Virus Hepatitis B (VHB) merupakan penyebab infeksi kronis virus di dunia. Mother to child transmission (MTCT) merupakan salah satu mekanisme penularan utama infeksi VHB. Ekspresi ASGP-R dapat diekspresikan diluar hepatosit, salah satunya di plasenta, kadar Anti HBs pada bayi merupakan salah satu penanda adanya kekebalan terhadap VHB
Tujuan : Untuk mengetahui hubungan antara ekspresi ASGP-R plasenta ibu positif HBsAg dengan respon awal vaksinasi hepatitis B bayinya
Metode : Desain penelitian adalah cros sectional. Didapatkan 30 sampel plasenta ibu positif HBsAg dan bayinya, di Makassar. Dilakukan analisis ekspresi ASGP-R plasenta dan kadar Anti HBs pada bayinya.
Hasil : Sebanyak 30 sampel ibu positif HBsAg didapatkan ekpresi ASGP- R plasenta rendah 24 (80%) sampel sedangkan ekspresi tinggi 6 (20%). Anti HBs bayi yang responsive sebanyak 24 orang (80%) dan non responsive sebanyak 6 (20%) Tidak ada hubungan yang bermakna antara jenis kelamin, usia gestasi kehamilan, berat bayi lahir, status HbeAg ibu dan status HbsAg bayi dengan respon anti Hbs bayi.Tidak ada hubungan antara ekspresi ASGP-R plasenta dengan respon anti HBs bayi dengan nilai p=1,000
Kesimpulan : Penelitian ini menunjukkan tidak ada hubungan antara ekpresi ASGP-R plasenta dengan respon anti HBs bayi.
Background :Hepatitis B virus (HBV) is the cause of chronic viral infection in the world. Mother to child transmission (MTCT) is one of the main transmission mechanisms of HBV infection. ASGP-R expression can be expressed outside hepatocytes, one of which is in the placenta. Anti-HBs levels in infants are one of the markers of immunity to HBV.
Aim :The purpose of this study was to determine the relationship between ASGP-R expression of HBsAg positive placenta and the initial response to hepatitis B vaccination of the baby
Method :The research design was cross sectional. There were 30 samples of placenta positive for HBsAg mothers and their babies, in Makassar. Analysis of placental ASGP-R expression and Anti-HBs levels were performed in the baby.
Results : A total of 30 samples of HBsAg positive mothers obtained low placental ASGP-R expression in 24 (80%) samples while 6 (20%) with high expression .Anti-HBs responsive infants were 24 (80%) and non- responsive were 6 (20%) There is no significant correlation between placental ASGP-R expression with the baby's anti-HBs response with p value = 1,000. There was no significant relationship between sex, gestational age, birth weight, maternal HBeAg status and baby HBsAg status with baby anti-HBs response .
Conclusion :This study showed that there was no correlation between placental ASGP-R expression and with baby's anti-HBs response.
Keywords : ASIALOGLYCOPROTEIN , HEPATITIS B, BAYI BARU LAHIR