ANALISIS HUBUNGAN GAMBARAN CT SCAN TORAKS DENGAN NILAI CYCLE THRESHOLD RT-PCR DAN KOMORBIDITAS PASIEN YANG TEKONFIRMASI COVID-19 = Analysis of the Correlation Between Thoracic CT Scan Findings and RT-PCR Cycle Threshold Values with Comorbidities in Confirmed COVID-19 Patients.

. Analysis of the Correlation Between Thoracic CT Scan Findings and RT-PCR Cycle Threshold Values with Comorbidities in Confirmed COVID-19 Patients. (Supervised by Bachtiar Murtala and Irawati Djaharuddin) This study aims to analyze the relationship between thoracic CT scan findings, RT-PCR cycle threshold values, and comorbidities in patients confirmed with COVID-19. CT scan is a modality that can be used not only for diagnosis but also to determine COVID-19 severity level, while RT-PCR is a specific examination for diagnosing COVID-19 based on the Cycle Threshold value. Clinical conditions from several studies indicate that patients with comorbidities exhibit greater severity compared to those without comorbidities. This research employs a cross-sectional observational design, analyzing CT scan findings of confirmed COVID-19 patients and documenting comorbidities along with RT-PCR Cycle Threshold values. The study was conducted on 634 cases, of which 387 individuals (60.2%) were male and 256 individuals (39.8%) were female. The most frequently identified finding was Ground-Glass Opacity (GGO), present in 386 cases (60%), followed by Fibrosis in 261 cases (40.6%), and Consolidation in 260 cases (40.4%). Pleural Effusion was next (22.1%), most frequently distributed bilaterally. Lesions were most commonly found in segment 10 of the right inferior lobe (69.7%), followed by segment 20 of the left inferior lobe (65.6%), with the most frequent involvement pattern observed in the posterior basal segment of the inferior lobe. Individuals with comorbidities had a 1.45 times greater risk of developing GGO lesions compared to individuals without comorbidities, a 1.7 times greater risk for consolidation, a 2.14 times greater risk for crazy paving, and a 2.89 times greater risk for air bronchograms. The comorbidities playing a significant role were Hypertension and Diabetes Mellitus. A difference was observed in CT Severity Scores between patients with and without comorbidities: a median score of 18 (IQR 21) for hypertensive patients and a median of 17 (IQR 22) for diabetic patients. This study found no correlation between RT-PCR Cycle Threshold values and CT Severity Scores. The conclusion drawn from this study is that GGO was the most common finding, associated with hypertensive comorbidity; consolidation and fibrosis were associated with Diabetes Mellitus comorbidity; and Pleural Effusion was associated with Pulmonary Tuberculosis comorbidity. The presence of comorbidities was significantly associated with a decrease in RT-PCR Cycle Threshold values, being 0.131 times lower.