Formulation and Pharmacological Studies of Leaves of Moringa (Moringa oleifera), a Novel Hepatoprotection in Oral Drug Formulations


Aristianti, Aristianti and Nurkhaeri, Nurkhaeri and Y. Tandiarrang, Vanny and Awaluddin, Akbar and Muslimin, Lukman (2021) Formulation and Pharmacological Studies of Leaves of Moringa (Moringa oleifera), a Novel Hepatoprotection in Oral Drug Formulations. Open Access Macedonian Journal of Medical Sciences..

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Abstract (Abstrak)

BACKGROUND: Moringa oleifera, Moringaceae, is a tree that is native to South East Asia. Various parts of this tree are commonly used in traditional medicine to treat inflammation, hepatitis, gastric ulcer, and other ailments. AIM: M. oleifera leaves extract was formulated into stable suspensions, characterized, and then evaluated for hepatoprotection activity against isoniazid. MATERIALS AND METHODS: The leaves were extracted using cold maceration, and suspensions of extract were prepared using sodium carboxymethyl cellulose (Na-CMC) as suspension agent at various concentrations (0.1, 0.5, and 1.0%). The formulations were analyzed by their appearance, color, odor, and taste. Density, pH, viscosity, re-dispersibility test, and sedimentation volume were observed. The stability of oral suspensions was analyzed in accelerated studies (5°C ± 2°C and 35°C ± 2°C for 12 h for 7 cycles) to find stable formulation, while the hepatoprotection activity was analyzed using an in vivo isoniazid-induced model. RESULTS: The appearance, color, odor, and taste of the suspensions were shown to be characteristic of the extract. Na-CMC at concentration 0.5% showed good physical properties. Stable suspension at dose 400 mg/kg BW per oral for 28 days exhibited a significant (p < 0.05) decrease in the serum glutamate oxaloacetate transaminase and serum glutamate pyruvate transaminase. CONCLUSION: Suspension containing M. oleifera leaves extract at 50 mg/5 mL was successfully obtained and showed physical properties that were appropriate and characteristic of this dosage form, suitable for hepatoprotection (400 mg/kg BW), making this an alternative to tablets.

Item Type: Article
Subjects: R Medicine > R Medicine (General)
Depositing User: - Andi Anna
Date Deposited: 01 Jul 2021 05:13
Last Modified: 01 Jul 2021 05:13
URI: http://repository.unhas.ac.id:443/id/eprint/5159

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