Preparation of Hydrogel-Based Chitosan Using Citric Acid as Cross-Linker and Dialdehyde Cellulose from Sugarcane Trash (Saccharum officinarum L.) for Matrices Drug Delivery

Hydrogel was a three-dimensional network that has a hydrophilic group, that can swell, and hold a large amount of water that can be applied in biomedical such as matrices of drug delivery. Preparation dialdehyde cellulose from sugarcane trash leaves (Saccharum officinarum L.) using Microwave-autoclave pretreatment by used oxalic acid and sodium hydroxide followed by oxidation using periodate was the experimental works effort. Dialdehyde cellulose (DAC) was used as hydrogel reinforcement with the Schiff base reactions towards chitosan. The citric acid as a cross-linker agent was used 10% (w/w). Their structural and functional properties were characterized by Fourier Transform Infrared (FTIR). This study found that the hydrogel can swell up to 3567% after 15 min in water and their application as a drug delivery matrix. Encapsulation efficiency of the hydrogel towards methylene blue ranged from 45 to 85%, with drug loading range from 22 to 23 mg/g and releasing for five hours.