EFFECTIVENESS OF FUCOIDAN IN STIMULATING OSTEOBLAST CELLS IN BONE REGENERATION

Background: There are several cases related to bone destruction in the oral cavity, such as complications from tooth extraction and periodontitis leading to alveolar bone loss. Tissue engineering can restore and repair a lost or damaged network function. One biomaterial that plays a role in bone regeneration is fucoidan from brown algae marine biopolymer, which contains biomaterials that can make new osteoblast cells. Purpose: In general, this literature review aims to find out that fucoidan can be used to stimulate the growth of osteoblast cells in bone regeneration. Result: From the journals that have been reviewed, it was found that fucoidan is helpful as a functional food and is a drug for osteoporosis, preventing bone loss, promoting bone formation in vitro and in vivo, as well as inhibiting excessive bone resorption. Conclusion: This review has shown that fucoidan is known
to have biological activities such as anticoagulant and antithrombotic, antioxidant and acts as a phenotypic marker in the early stages of osteoblastic differentiation resulting in an increase in osteogenic marker genes such as Alkaline Phosphatase (ALP), osteocalcin, Bone Morphogenetic Protein-2 (BMP). -2) RUNX-2, Col. 1, and OPN.