BALANCE CAIRAN POSITIF SEBAGAI FAKTOR PROGNOSTIK PASIEN ANAK DENGAN SEPSIS = POSITIVE FLUID BALANCE AS A PROGNOSTIC FACTOR FOR SEPTIC CHILDREN

ASTRI: Positive Fluid Balance As A Prognostic Factor For Septic Children (Supervised by St Aizah Lawang and Idham Jaya Ganda). Background: Sepsis is one of the leading causes of infant and child morbidity and mortality worldwide. Fluid administration is an important way to reduce morbidity and mortality in septic patients with low blood flow and shock, since sepsis is often linked to low blood volume. This study aimed to investigate the relationship between positive fluid balance and the outcome of pediatric sepsis patients. A retrospective cohort study at the Pediatric Insentive Care Unit (PICU) of Dr. Wahidin Sudirohusodo, Makassar. The study was conducted from December 2021 to Mei 2022. Hospitalized patients aged 1 month to 18 years with clinical signs and laboratory markers of sepsis who met the inclusion and exclusion criteria were the population of this study. Positive fluid balance was found to have a significant link with the outcome of pediatric sepsis patients (p<0.05). The positive fluid balance value of ≥4.61% was associated with mortality in pediatric patients with sepsis, with a sensitivity value of 62.79%, specificity of 62.16%, negative predictive value of 58.95%, and positive predictive value of 65.85%. The value of positive fluid balance in the first 24 hours of PICU care was higher in septic pediatric patients who died compared to those who improved, but not significantly (p=0.37). The value of positive fluid balance during PICU care was higher in septic pediatric patients who died compared to those who improved (p<001). Positive fluid balance with a cut-off value of 4.61% can be used as a prognostic factor in pediatric patients with sepsis.

Keywords: Fluid Balance, Sepsis, Children, Mortality