Hubungan Antara Kadar Alpha Klotho Serum Dengan Hipertrofi Ventrikel Kiri Pada Pasien Penyakit Ginjal Kronik = Association Between Alpha Klotho Serum Level With Left Ventricular Hypertrophy In Chronic Kidney Disease Patients

A. Purnamasari : ASSOCIATION BETWEEN ALPHA KLOTHO’S SERUM LEVEL WITH LEFT VENTRICULAR HYPERTROPHY IN CHRONIC KIDNEY DISEASE PATIENTS.
Introduction : In chronic kidney disease (CKD), the α-Klotho level serum, a protein that is mainly expressed in the kidneys and has various functions, including as a co-receptor of fibroblast growth factor-23 (FGF-23), which helps increase the phosphate excretion in the kidney and has anti-fibrotic, anti-proliferative, anti-inflammatory, and protective effects on the endothelium, is in deficient state. Low serum α-Klotho level have been linked to cardiac remodeling and left ventricular hypertrophy (LVH). The purpose of this study was to understand the relationship between α-Klotho level, left ventricular mass index, and LVH event in CKD patients.
Methods : This cross-sectional study involved 74 CKD subjects with stage 3 (n=18), stage 4 (n=19), stage 5 non-dialysis (n=20) and stage 5 dialysis (n=17) distribution at Wahidin Sudirohusodo Hospital and Hasanuddin University Hospital Makassar from August 2022 until October 2022. The ELISA (enzyme-linked immunosorbent assay) kit method was used to determine the α-Klotho level. Echocardiography is performed by an experienced cardiologist.
Results : There was a negative correlation between serum α-Klotho level and left ventricular mass index(LVMI) (R = -0.119), and the mean value of serum α-Klotho level was lower in LVH subjects than non-LVH subjects, 522.7 pg/ml versus 554.5 pg/ml, but this was not statistically significant (p>0.05). Obtained LVH risk factors, such as gender, age, obesity, hypertension, and diabetes mellitus, are independent of the incidence of LVH in CKD.
Conclusion : In this study, there was no statistically significant correlation between α-Klothos’s serum level with incidence of left ventricular hypertrophy in chronic kidney disease patients.

Keywords : α-Klotho, left ventricular hypertrophy, chronic kidney disease