Profil Asam Urat Pada Berbagai tingkat Derajat Non-Alcoholic Fatty Liver Disease (NAFLD)

ABSTRAK Rasdiana: Profil Asam Urat Pada Berbagai Tingkat Derajat Non-Alcoholic Fatty Liver Disease (NAFLD) (dibimbing oleh Faridin HP, Fardah Akil ) Latar Belakang: Perlemakan Hati Non Alkoholik (Non Alcoholic Fatty Liver Disease/NAFLD) merupakan salah satu penyebab utama dari penyakit hati kronis di seluruh dunia. Non-alcoholic fatty liver disease terdiri dari dua kondisi patologis yang berbeda, yaitu steatosis dan steatohepatitis Beberapa studi menunjukkan hubungan kuat antara hiperurisemia dan NAFLD. Oleh karena itu penelitian ini dilakukan untuk mengetahui hubungan kadar asam urat dengan kejadian NASH pada NAFLD (Non Alcoholic Fatty Liver Disease) dengan dan tanpa obesitas. Metodologi: Subjek pada penelitian 149 pasien yang terdiagnosis NAFLD. Data dikumpulkan dari data Rekam medik dengan metode purposive sampling. Subjek diambil dari data pasien rawat inap dan rawat jalan di RS Wahidin Sudirohusodo. Catatan medis terdiri dari demografi,klinis serta pemeriksaan penunjang radiologi dan laboratorium. Penilaian derajat NAFLD berdasarkan hasil Radiologi dan pemeriksaan enzim transaminase. Analisis data dilakukan dengan menggunakan SPSS versi 22. Uji statistik penelitian ini menggunakan pearson correlation dan logistik multinomial. Hasil: Hasil dari penelitian ini, didapatkan korelasi yang signifikan antara NAFLD dan kadar asam urat (p= 0.000). Berdasarkan jenis kelamin didapatkan korelasi antara NAFLD dan urisemia signifikan pada wanita (dengan p = 0.000); tetapi tidak signifikan pada pria (p =0.137). Berdasarkan usia, pada kelompok usia>40 tahun terdapat korelasi yang signifikan antara NAFLD dan asam urat (p = .000). Terdapat korelasi yang signifikan antara hiperurisemia dengan NASH pada pasien obese dan non obese (p<0,001), dimana semakin tinggi kadar asam urat semakin berat derajat NAFLD. Kesimpulan: Hasil dari studi ini menunjukkan terdapat korelasi kadar asam urat dengan kejadian NASH pada NAFLD (Non Alcoholic Fatty Liver Disease) dengan dan tanpa obesitas. ABSTRACT Rasdiana: Uric Acid Profile at Various Degrees Of Non-Alcoholic Fatty Liver Disease (NAFLD) (dibimbing oleh Faridin HP, Fardah Akil ) Background: Non-alcoholic fatty liver disease (NAFLD) is one of the most common cause of chronic liver disease in developing countries. Non-alcoholic fatty liver disease consists of steatosis and steatohepatitis. Several study show closed association between hyperuricemia and NAFLD. Furthermore, this study intend to know relationship between uric acid levels and NASH on NAFLD with and without obesity. Methods: The research subjects were 149 patients diagnosed with NAFLD. Data were collected from the medical record by purposive sampling method. The subjects were taken from inpatient and outpatient data in Wahidin Sudirohusodo hospital. The medical record consists of demography, clinical, radiology and laboratory. NAFLD level evaluation was based on the result of Radiology and transaminase enzyme examination. Statistic test in this study were Pearson Correlation and multinomial logistic. Results: There was a significant correlation between NAFLD and uric acid level (p=0.000). Based on gender, the correlation between NAFLD and uricemia was significant in female (with p=0.000); but insignificant in male (p=0.137). Based on age, in age of >40 years old there was a significant correlation between NAFLD and uric acid level (p=0.000). There was a significant correlation between hyperuricemia and NASH in obese and non-obese patients (p<0.001), where the higher the uric acid level the greater NAFLD degree. Conclusion: There is a correlation between uric acid level and NASH occurrence in NAFLD with or without obesity.