HUBUNGAN UKURAN TUMOR DAN GRADING HISTOPATOLOGI DENGAN SUBTIPE MOLEKULER KANKER PAYUDARA DI RS WAHIDIN SUDIROHUSODO MAKASSAR

Breast cancer (BC) is the second most frequent cancer-related death among women
worldwide. Factors influencing BC patients‟ survival include histopathological grade,
histopathological type, stage, hormonal receptors, and number of mitotic images. To
compare the tumor size, histopathological grade, and molecular type of BC patients.
This was an observational analytic retrospective study. The population was BC patients
at Wahidin Sudirohusodo Hospital from 2017 to 2021. The Kruskal–Wallis test was
used to compare statistically between tumor size, histopathological grade, and molecular
subtype. Significance was set at p < 0.05. The study included 784 patients. Most were
aged 50–59 years (34.8%), with tumor size 4c (37.0%) and moderate grade (66.1%),
and the most common molecular subtype was luminal A (34.2%). Bivariate analysis
using the Kruskal–Wallis test found no significant difference in molecular subtypes
based on tumor size (p = 0.079), but significant differences existed in molecular subtype
by histopathological grade (p = 0.005) and (p < 0.001). Significant differences existed
between histopathological grade by tumor tumor size by histopathological grade size
and molecular subtype. Early diagnosis and prompt treatment of BC patients are
important to prevent morbidity and mortality.