KHASIAT PEMBERIAN PROBIOTIK SACCHAROMYCES BOULARDII TERHADAP KADAR HEMOGLOBIN, RETIKULOSIT, RETIKULOSIT HEMOGLOBIN, RED DISTRIBUTION WIDTH PADA PENGOBATAN ANAK DENGAN DEFISIENSI BESI

Pendahuluan : Saccharomyces boulardii merupakan probiotik jenis ragi yang saat ini mulai berkembang penelitiannya untuk diketahui pengaruhnya terhadap berbagai macam penyakit dan diharapkan dapat menjadi solusi potensial dalam menanggulangi anemia defisiensi besi.
Tujuan : Menilai khasiat probiotik Saccharomyces boulardii pada pengobatan anak dengan defisiensi besi.
Metode : Desain penelitian ini adalah randomised control trial (RCT), double blind. Penelitian dilakukan terhadap 400 orang anak usia 1 – 18 tahun di 15 LKSA yang ada di kota Makassar.
Hasil : Total 94 orang anak dengan defisiensi besi terdiri atas 2 kelompok secara random. 46 anak mendapat plasebo bersama terapi standar dan 48 anak mendapat S. boulardii bersama terapi standar. Terapi diberikan selama 7 hari, kemudian dinilai kadar hemoglobin, retikulosit, Ret-He, dan RDW-SD antar kedua kelompok. Kadar Ret-He pada kelompok S. boulardii lebih tinggi disbanding kelompok kontrol dengan nilai p = 0.037 (p < 0.037). Sedangkan kadar hemoglobin, retikulosit, dan RDW-SD pada kelompok S. boulardii lebih rendah disbanding kelompok kontrol (p = 0.5.35, p = 0.914, p = 0.433) . Tidak terdapat perbedaan signifikan terhadap selisih kadar hemoglobin, retikulosit, Ret-He, dan RDW-SD antara kelompok placebo dan S. boulardii
Kesimpulan : Anak dengan defisiensi besi yang mendapat S. boulardii bersama terapi standar selama 7 hari menunjukkan kadar Ret-He yang lebih tinggi daripada yang mendapatkan plasebo bersama terapi standar.

Background : Saccharomyces boulardii is a yeast type probiotic which research is recently starting to develop to determine its effect on various diseases and is expected to be a potential solution in overcoming iron deficiency.
Objective : The aim of this study to assest the efficacy of the probiotic Saccharomyces boulardii in of children with iron deficiency therapy.
Methods : The study design was a randomized control trial (RCT), double blind. The study was conducted on 400 children aged 1-18 years in 15 orphanage in the city of Makassar.
Result : A total of 94 children with iron deficiency were randomized into 2 groups. Fourty-six children received placebo with standard therapy, whereas the other 48 received S. boulardii with standard therapy. Therapy was given for 7 days, then assessed hemoglobin, reticulocyte, Ret-He, and RDW-SD levels between the two groups. Ret-He value in the S. boulardii group were higher than the control group with p = 0.037 (p < 0.05). However, hemoglobin, reticulocytes, and RDW-SD values in the S. boulardii group were lower than in the control group (p = 0.535, p = 0.914, p = 0.433, respectively). There was no significant difference in the difference in hemoglobin, reticulocyte, Ret-He, and RDW-SD levels between the placebo and S. boulardii groups.
Conclusion : Children with iron deficiency receiving S. Boulardii with standard therapy for 7 days show higher Ret-He levels than those receiving placebo with standard therapy.