Usage of Asian African Leaf (Vernonia amygdalina) AsAnalgesic during Post Tooth Extraction in Rabbit (Rattus norvegicus) In Vivo Gel Spray Form

Background: Tooth extraction has a detritemental effects, namely disturbance in the masticatory function, unpleasant aesthetics, disturbed phonetics, temporomandibular dysfunction, pain, psychological problem and decreased level of trust and self confident these are the complications of the aforementioned problem.
Aim: In treating the complication that is marked by pain in the patient, there needs to be analgesic after tooth extraction, however some people dislike the idea of drug consumption, especially if it has to be ingested orally. With that in mind, Vernonia amygdalina in gel spray form is made to help treat post tooth extraction pain. Methods: Four formulas were used, F1 (5% NaCMC), F2 (3% NaCMC), F3 (1% NaCMC) and F4 (carbopol) to evaluate the suitable formula for gel spray making, the evaluations are organoleptic testing, purity, viscosity, pH and spraying model.
Result: Based on the evaluating data we conclude that F3 is the suitable formula. Then, it mixes with the 5% extract and we use rabbit that has been tooth extraction as the trial animal to see the analgesic effect of the extract and it considers with mefenamic acid as the positive controlled.
Conclusion: The results of this study showed that Asian African leaf ethanol extract (Vernonia amygdalina) posseses an anlgesic effect or relieved post-rabbit dental extraction given topically by spray gel preparation. Due to the presence of flavonoids, tannins, and saponins.